Research and development

R & D

Advanced bioprocess control Nicro provides turnkey solutions for fermenters


From time consuming sample analysis to real-time monitoring of critical parameters in fermentation processes thanks to complete solutions from hardware to development and analytical services.

The results:
• Safe operation and time saving thanks to in-line process monitoring of metabolites without the need for sampling
• Improved process control leading to optimised production and increased yield
• Complete packaged solution for fermentation  


The customer challenges A typical indicator of fermentation progress is the lack of dissolved oxygen in the media which gives an estimation
of the process duration. Optical density and metabolites may also be monitored for a better insight into the
process. Concentration of metabolites  would usually be measured off-line with time consuming chromatographic techniques and therefore would

require samples. This can also bring a potential risk of contamination and lead to the loss of a valuable batch.

Our solutions Nicro combined their competencies together with BIOCentre and Endress+Hauser to provide

a complete packaged solution for fermentation processes. It includes:

• Engineering and design of complete fermentation system from Nicro

• Kaiser Raman Rxn™ analyzer and BioProbe from Endress+Hauser

• Analytical Services from BIOCentre supported by S-PACT modelling services.